Hematology

The Central National Biobank collects the set of biosamples from patients with all types of hematological malignancies in the chronic and crisis stages of the disease including:

• Acute myeloid leukemia (AML)
• Chronic myeloid Leukemia (CML)
• Acute lymphoblastic leukemia (ALL)
• Chronic lymphocytic leukemia (CLL)
• Multiple myeloma (MM)
• Myelodysplastic syndrome (MDS)

Biological specimens obtained from these patients are intended for further molecular studies in order to verify the safety of created drugs, develop new methods of treatment and search for biomarkers of diseases’ development.

The team of the Central National Biobank works closely with leading Russian clinical and research centers specializing in oncohematology.
Standard protocols for the collection, processing and storage of biological specimens from patients with clinically defined hematologic diseases include:

• Collection of blood products (serum, plasma) and isolation of peripheral blood mononuclear cells (PBMC)
• Bone marrow aspirate collection and preparation of viable or frozen mononuclear cells (BMMC)
• Preparation of Formalin-fixed Paraffin-embedded tissue specimen blocks (FFPE) with bone marrow samples after biopsy
• Creation of a collection of quick-frozen tissues for a number of hematologic diseases